College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 2

All eyes are on Texas this weekend as the biggest game of this early 2026 season unfolds in Austin.

No. 1 Ohio State at No. 4 Texas is the kind of blockbuster contest missing from the Week 1 slate, though Ole Miss-Louisville, Western Michigan-Michigan and others did their best to entertain us. It’s a rematch of last season’s opener in which Arch Manning struggled in his starting debut and the Buckeyes held on for a 14-7 win.

There have been significant changes on both sides since Week 1 of 2025. For Texas, there are new offensive weapons (Cam Coleman, Hollywood